Side Effects

What’s normal, what helps, and when to call your clinician

Are side effects normal?

If you’re using a GLP-1 medication (like semaglutide), it’s common to notice changes in appetite and digestion, especially in the first few weeks or after a dose increase.
The key thing to remember: every body is different. Some people feel almost nothing, others feel side effects that come and go, and many notice improvement as their body adapts.

Common side effects (possible)

The most commonly reported side effects include nausea, diarrhea, vomiting, constipation, stomach/abdominal pain, headache, fatigue, indigestion/heartburn, bloating, belching, and gas.

Start with these “baseline” habits (often enough for mild symptoms)
  • Eat smaller meals and slow down while eating.

  • Avoid greasy/heavy meals when you feel sensitive.

  • Prioritize protein in smaller portions (it helps you stay nourished even when appetite is low).

  • Hydrate consistently - sipping throughout the day is often easier than chugging.

  • Increase fiber slowly (adding too much too fast can worsen bloating).

Many of these are connected to slowed digestion and reduced appetite. They can be more noticeable:

  • during the first weeks

  • after dose increases

  • after larger, richer, or higher-fat meals

Nausea & upset-stomach toolkit

Use what fits your body - this is about comfort and consistency, not perfection.

Try first (low-friction)
  • Ginger chews or ginger tea - a simple, travel-friendly option many people like to keep on hand.

  • Peppermint tea - soothing after meals for some people.

  • Electrolyte packets - helpful if nausea makes it harder to drink enough fluids.

Drug-free option some people love:


If nausea is persistent:
Talk to your clinician about strategies and whether an OTC option is appropriate for you.

Constipation & “slow digestion” toolkit

Constipation can happen when digestion slows and food intake drops. If you’re uncomfortable, don’t just “push through”—build a gentle routine.

Step 1: fluids + fiber (go slow)


Step 2: gentle options (as needed)

  • PEG 3350 (MiraLAX-style) - a commonly used gentle option for occasional constipation (check label + ask your clinician if unsure).

  • Stool softener (docusate) - some people prefer this approach when stools are hard/dry.


Support items

  • Magnesium glycinate - many people use it for regularity/sleep support, but tolerance varies (start low, follow label, and check with your clinician if you’re on meds or have kidney issues).

Heartburn, gas, bloating (common “annoying” ones)

Because GLP-1s can slow digestion, some people notice heartburn, burping, gassiness, or bloating.

Helpful options:

Simethicone (gas relief) for bloating/gas discomfort.

Famotidine (acid reducer) for heartburn/acid indigestion - follow label directions and check with your clinician if you’re taking other medications.

When to call your clinician urgently

Stop guessing and get medical advice right away if you have:

severe or persistent abdominal pain, especially with vomiting, fever, chills, or feeling faint

signs of dehydration (can’t keep fluids down, dizziness, very dark urine)

blood in stool, black/tarry stools, or severe constipation with worsening pain

symptoms that are getting worse instead of better

(Your clinician would rather you call early than wait too long.)